Journal of Animal and Veterinary Advances
ISSN: Online 1993-601XISSN: Print 1680-5593
Abstract
In cancer treatment, the main objectives are to concentrate the chemotherapeutically applied substance on the targeted tissue as specifically as possible and to minimize its effect on other cells until it reaches the target tissue. Different pharmaceutically developed drug delivery systems for this purpose have been tried for many years and are currently in use in practice. Bacterial ghosts (BG), which have been developed in recent years, are non‐living bacterial structures that are usually obtained as a result of various processes of gram (‐) bacteria, evacuated and consisting only of cell wall. The use of the emptied cytoplasmic compartments of ghost bacteria as a transport system by loading them with various pharmaceuticals seems to serve this purpose. Thus, it is expected that pharmaceuticals, which are mostly known to have cytotoxic properties, are transported to the cancerous area in a controlled and safe manner. In addition, since BGs do not completely lose their surface structures (pathogen‐related patterns) they will have the ability to stimulate the immune system, a second expected benefit will be the adjuvant effect. In the present review, the information on the use of ghost bacteria systems as a transport system for chemotherapeutic agents used in cancer therapy is compiled.
How to cite this article:
Banu Atalay. Use of Bacterial Ghosts as a Delivery System in Cancer Theraphy.
DOI: https://doi.org/10.36478/10.59218/makjava.2023.15.18
URL: https://www.makhillpublications.co/view-article/1680-5593/10.59218/makjava.2023.15.18