Research Journal of Medical Sciences
ISSN: Online 1993-6095ISSN: Print 1815-9346
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Abstract
Celiac disease is an immune‐mediated disorder caused by gluten intolerance, primarily affecting the gastrointestinal mucosa. Diagnosis involves serologic tests and biopsy, with a lifelong gluten‐free diet as treatment. This study aimed to explore the correlation between histopathology and serology in pediatric celiac disease patients. The objectives were to study histopathology using Marsh criteria and to assess the correlation between tissue transglutaminase antibody (tTGA) levels and clinical presentation in pediatric patients. The study was a retro‐prospective study of three years ( January 2015‐ January 2016 and January 2021 ‐January 2023). Fifty cases were included, with biopsies graded according to the Oberhuber‐modified Marsh criteria. Data on age, clinical features and tTGA levels were recorded and analyzed using SPSS software. The most common age group was 2.0‐5.9 years, with a slight female preponderance (54%). Diarrhea was the most common clinical symptom. Serology showed that 78% of cases were tTGA‐positive. Histopathologically, 42% had mild villous atrophy and 36% had moderate atrophy. tTGA levels significantly correlated with higher Marsh stages (P<0.001). TTGA levels showed a positive correlation with histopathological severity, aligning with Marsh‐Oberhuber grading in pediatric celiac disease patients.
How to cite this article:
Sonali Jain, Deepika Kesarwani, Akanksha Singh and Avinash Pradhan. An Observational Study of Serological and Histopathological Correlation of Celiac Disease in Pediatric Patients.
DOI: https://doi.org/10.36478/10.36478/makrjms.2024.10.294.298
URL: https://www.makhillpublications.co/view-article/1815-9346/10.36478/makrjms.2024.10.294.298