TY  - JOUR
T1  - Proteomics Approaches for the Early Detection and Diagnosis of Cancer
AU - Hosseini, Saman AU - Behrad Khamesee, Mir 
JO  - Journal of Molecular Genetics
VL  - 13
IS  - 2
SP  - 46
EP  - 56
PY  - 2021
DA  - 2001/08/19
SN  - 2070-4267
DO  - jmolgene.2021.46.56
UR  - https://makhillpublications.co/view-article.php?doi=jmolgene.2021.46.56
KW  - early detection
KW  -cancer
KW  -Proteomics
KW  -biomarkers
KW  -protein
AB  - Thousands of patients are annually diagnosed
with cancer in Iran and around the globe. The early
detection and diagnosis of cancer, the tumorigenesis is in
its early phase is crucial for its ultimate control and
prevention. Today, the number of people who die from
cancer, compared to three decades ago, have declined.
Identifying the nature and development of cancer have
always attracted a lot of attention from clinicians and
scientists. Understanding the cellular changes alone in
living species requires basic molecular investigations.
Recent advances in molecular biology have been of great
help researcher’s understanding the complex interaction
of genetic alteration, transcription and translation of
human cancer. Proteomics studies could play an important
role in prevention, early detection and treatment of
cancer. Early stage detection is the key to obtain a better
outcome for therapeutic intervention of cancer. Although,
advances in early stage detection of cancer have come of
great help to cancer treatment, most routine screening and
diagnosis tools lack sufficient sensitivity and specificity
of molecular approaches such as proteomics. With the
proteomic technologies emerging, classification and
identification of body fluid proteins have been a major
focus of scientists. Proteomic analyses have opened a
new horizon in screening changes happening in cellular
processes to become cancerous, however, it is yet to be
perfected using complementary approaches for more
accurate diagnosis of cancers. A combination of
proteomics approaches like Ciphergen Protein Chip
Arrays and SELDI-TOF MS with bioinformatics tools
was proved to be effective in the discovery of new
biomarkers which further helps the early-stage detection
and diagnosis of cancer.
ER  -