TY  - JOUR
T1  - Impact of IL1, IL6, IL8, IL17 and TGF Gene Polymorphisms in Bladder Cancer Patients
AU - Ahmwd Jasim, Hamsa AU - Jwad Hamza, Subhi AU - Ahmed Shamran, Haidar AU - Zuhair Naji, Rana 
JO  - Journal of Molecular Genetics
VL  - 11
IS  - 2
SP  - 14
EP  - 19
PY  - 2019
DA  - 2001/08/19
SN  - 2070-4267
DO  - jmolgene.2019.14.19
UR  - https://makhillpublications.co/view-article.php?doi=jmolgene.2019.14.19
KW  - Single Nucleotide Polymorphism (SNPs)
KW  -interleukin-1
KW  -interleukin-6
KW  -interleukin-8
KW  -interleukin-17 and TGF
KW  -bladder cancer
KW  -PCR
AB  - Bladder cancer is one of the most common
cancers worldwide and the most frequent malignancy of
the urinary tract recently, several Single Nucleotide
Polymorphisms (SNPs) have been identified in cytokine
gene sequences, particularly within the promoter region of
these genes and have been shown to be associated with
the development of bladder cancer. The present study
investigates the association of IL1, 6, 8, 17 and TGF
polymorphisms with the incidence of bladder cancer.
Blood samples were collected from 50 histologically
confirmed adult patients with bladder cancer and 28
apparently healthy individuals. DNA was extracted from
each blood sample and the genes were amplified using
Polymerase Chain Reaction (PCR) with gene-specific
primers target. Systemic IL1β, 6, 8, 17 and TGFβ,
concentration was assessed in serum samples from each
participant by Enzyme-Linked Immunosorbent Assay
(ELISA). A appositive association between the allele T of
the SNP rs 16944 of IL 1 gene (p = 0.005, OR = 4.263,
95% CI = 1.566-11.603) and the allele G of the
SNP rs 1800469 of TGFβ gene (OR = 0.19,
95% CI = 0.035-1.02) were found. These data indicate an
etiological role of IL-1β and TGF gene polymorphism in
bladder cancer.
ER  -