TY  - JOUR
T1  - The Genetic Base For Drug Addiction
AU - N. Qadr, Srwsh 
JO  - Journal of Aquaculture Feed Science and Nutrition
VL  - 11
IS  - 3-4
SP  - 19
EP  - 25
PY  - 2019
DA  - 2001/08/19
SN  - 2070-1667
DO  - joafsnu.2019.19.25
UR  - https://makhillpublications.co/view-article.php?doi=joafsnu.2019.19.25
KW  - Gene
KW  -food
KW  -addiction
KW  -GWAS
KW  -food
AB  - There are many evidences about relationship
between eating behavior and drug addiction. A number of
susceptibility loci that point to shared higher order genetic
pathways underling addiction were found in genetic
studies. This study assumed that a Genome-Wide
Association Study (GWAS) of food addiction would
produce important enrichment in genes and pathways
related to addiction. This study done among 314 women
of European ancestry by using a GWAS of food addiction
which is determined by the modified Yale Food Addiction
Scale (mYFAS). Results for enrichment of Single
Nucleotide Polymorphisms (SNPs) (n 5 44), genes (n 5
238) and pathways (n 5 11) involved in drug addiction
were tested. Two loci met GW-significance (p<2.5 10<sup>-8</sup>)
with no obvious roles in eating behavior, they are
mapping to 17q21.31 and 11q13.4. GW results were
significantly enriched for gene members of the MAPK
signaling pathway (p = 0.02). SAfter adjustment for
multiple testing, candidate SNP or gene for drug addiction
was not linked with food addiction. Limited support was
delivered for shared genetic underpinnings of drug
addiction and food addiction, although, the GWAS of
mYFAS, need further investigation and follow up.
ER  -