TY  - JOUR
T1  - Effects of Different Doses of Viper Cerastes cerastes Crude Venom on the Serum and Some
Enzyme Activities in Male Guinea Pigs at Different Times
AU - M.A. Salman, Muhammad 
JO  - Veterinary Research
VL  - 8
IS  - 4
SP  - 37
EP  - 44
PY  - 2015
DA  - 2001/08/19
SN  - 1993-5412
DO  - vr.2015.37.44
UR  - https://makhillpublications.co/view-article.php?doi=vr.2015.37.44
KW  - Viper Cerastes cerastes venom
KW  -biochemical parameters
KW  -enzyme activities
KW  -guinea pigs
KW  -post-injection
KW  -triglycerides
AB  - The desert horned vipers (<i>C. cerastes</i> and<br>
<i>C. gasperettii</i>) are the most familiar snakes of the great<br>
deserts of North Africa and the Middle East. In the<br>
present study, the effects of Cerastes crude venom on<br>
serum biochemical parameters of Guinea pigs. Female<br>
Guinea pigs (300&plusmn;30 g B.W.) were divided into three<br>
groups (10 each). In the control group, Guinea pigs were<br>
interaperitoneally (ip) injected with 100 &mu;L saline<br>
solution. The second group was ip., injected with<br>
0.2 &mu; g<sup>&#150;1</sup> B.W. of crude venom in 100 &mu;L saline solutions.<br>
The third group was ip., injected with 0.4 &mu;gm g<sup>&#150;1</sup><br>
B.W. of crude venom in 100 &mu;L saline solution. The<br>
results indicated that the single dose of crude venom<br>
induced a significant decrease in total serum protein,<br>
albumin, globulin cholesterol, triglycerides and uric acid<br>
within 12 and 24 h. After injection of crude venom<br>
of the viper C. cerastes. However, the levels of glucose,<br>
urea, creatinine, Alanine aminotransferase (ALT),<br>
Aspartate aminotransferase (AST) and Alkaline<br>
Phosphatase (ALP) were elevated in envenomated Guinea<br>
pigs after 12 and 24 h post-injection of crude venom.<br>
Viper C. cerastes crude venom caused hepatic and renal<br>
dysfunction in envenomated Guinea pigs. These<br>
disturbances are remaining for 24 h after envenomation of<br>
Guinea pigs at least, regardless the using dose.
ER  -