TY  - JOUR
T1  - Effects of Crude Aqueous Extract of <I>Ocimum gratisssimum</I> Leaves on Testicular Histology and Spermiogram in the Male Albino Rat (<I>Wistar strain</I>)
AU - Leigh, Olufisayo O. AU - Fayemi, Oluremi E. 
JO  - Veterinary Research
VL  - 2
IS  - 3
SP  - 42
EP  - 46
PY  - 2008
DA  - 2001/08/19
SN  - 1993-5412
DO  - vr.2008.42.46
UR  - https://makhillpublications.co/view-article.php?doi=vr.2008.42.46
KW  - Aqueous extract
KW  -ocimum
KW  -testicular histology
KW  -spermiogram
KW  -reproduction
KW  -rat
AB  - The effects of the aqueous leaf extract of <I>Ocimum gratisssimum</I> on testicular histology and spermiogram were investigated using 18 male albino rats. The rats were randomly divided into 3 groups: A-C, each containing 6 rats. Fifty grams of fresh leaves of <I>Ocimum gratisssimum</I> were rinsed, thoroughly blended in 100 mL of distilled water and filtered through filter paper. A 10x10<SUP>-4</SUP> and 5x10<SUP>-4</SUP> mL kg<SUP>-1</SUP> of the filtrate were administered to groups A and B, respectively thrice weekly for 5 weeks. Group C served as control and received distilled water. Histopathology revealed mild to severe congestion and edema as well as germinal tissue erosion of the seminiferous tubules. Spermatozoa motility, concentration, live-dead ratio and semen volume did not show significant changes (p&gt;0.05). However, differences in spermatozoa abnormalities between control and tested groups were highly significant (p&lt;0.01). Mean differences in sperm abnormalities between groups A (28.5), B (13.75) and the control were also greater than calculated Least Significant Difference (LSD) value of 2.146. These findings indicate antifertility properties of <I>Ocimum gratisssimum</I>.
ER  -