TY  - JOUR
T1  - Pharmacokinetics of Tulathromycin in Rabbits after Single Intravenous and Intramuscular Administration
AU - Goudah, A. AU - Hasabelnaby, S. 
JO  - Research Journal of Animal Sciences
VL  - 8
IS  - 2
SP  - 12
EP  - 17
PY  - 2014
DA  - 2001/08/19
SN  - 1993-5269
DO  - rjnasci.2014.12.17
UR  - https://makhillpublications.co/view-article.php?doi=rjnasci.2014.12.17
KW  - Tulathromycin
KW  -rabbits
KW  -pharmacokinetics
KW  -protein binding
KW  -bioavailability
AB  - The target of the present study was to investigate the plasma 
  disposition kinetics of tulathromycin in rabbits (n = 20) following a single 
  intravenous (i.v.) bolus or intramuscular (i.m.) injection at a dose rate of 
  2.5 mg kg<SUP>-1</SUP> B.W. using a parallel design. Plasma samples were collected 
  at appropriate times during a 216 h administration interval and were analyzed 
  using a Microbiological Assay Method. The plasma tulathromycin disposition was 
  best fitted to a Two Compartment Open Model after i.v. dosing. The half-lives 
  of distribution and elimination were 0.31&plusmn;0.07 and 61.83&plusmn;8.43 
  h, respectively. The volume of distribution at steady-state was 10.32&plusmn;1.26 
  L kg<SUP>-1</SUP>, the total body clearance (Cl<SUB>tot</SUB>) was 0.13&plusmn;0.07 
  L/kg/h and the areas under the concentration-time curves (AUC) was 22.56&plusmn;2.21 
  &#956;g/mL/h. Following i.m. administration, the mean t<SUB>1/2el</SUB> and 
  AUC values were 103.28&plusmn;17.65 h and 24.61&plusmn;2.15 &#956;g/mL/h. The 
  bioavailability was high (102.59&plusmn;12.82%) with a peak plasma mean concentration 
  (C<SUB>max</SUB>) of 0.76&plusmn;0.11 &#956;g mL<SUP>-1</SUP> attained at 0.81&plusmn;0.06 
  h (T<SUB>max</SUB>). The <I>in vitro </I>protein binding percentage was 29.5.
ER  -