TY  - JOUR
T1  - Trial of <I>Aspergillus fumigatus</I> Vaccine in Broiler Chicks
AU - Kwanashie, Clara N. AU - Umoh, Jarlath U. AU - Kazeem, Haruna M. AU - Abdu, Paul A. 
JO  - Research Journal of Animal Sciences
VL  - 6
IS  - 4
SP  - 72
EP  - 75
PY  - 2012
DA  - 2001/08/19
SN  - 1993-5269
DO  - rjnasci.2012.72.75
UR  - https://makhillpublications.co/view-article.php?doi=rjnasci.2012.72.75
KW  - Aspergillosis
KW  -aflatoxin
KW  -aspergillus
KW  -poultry
KW  -vaccine
AB  - There is a scarcity of information on the effect of vaccine against aspergillosis in Zaria and Kaduna areas. Thus, this study was conducted to determine the efficacy of an <I>Aspergillus fumigatus</I> germling vaccine. The methodologies used in this study included Aspergillus spore production, determination of LD<SUB>50</SUB>, preparation of the germling vaccine and testing the efficacy on broiler chicks. Three groups of 4 days old broilers were exposed to 4.2-5.8x10<SUP>8</SUP> cfu g<SUP>-1</SUP> lung tissue of <I>A</I>. <I>fumigatus</I>. The calculated amount of <I>A</I>. <I>fumigatus </I>that killed 50% of the broilers was 5.8x10<SUP>7.4</SUP>. <I>A. fumigatus</I> was recovered 4 weeks post exposure. A germling vaccine of <I>A. fumigatus </I>was administered to 4 days old broilers using the ocular route. The trial vaccine showed 40% protection when administered to chicks 2 weeks prior to challenge with <I>A. fumigatus </I>spores. It is recommended that levels of <I>A. fumigatus</I> spores should not rise to 5.8x10<SUP>7.4</SUP> cfu g<SUP>-1</SUP> lung tissue in poultry houses. Adjuvants can be added to the vaccine to raise the level of protection using different routes of administration and vaccinating at an older age.
ER  -