TY  - JOUR
T1  - Effectiveness of <em>Allium sativum</em> L. Ethanol Extract on the Growth of
<em>Trichophyton rubrum, Trichophyton mentagrophytes, Candida
albicans</em> and <em>Candida tropicalis</em>
AU - Lutpiatina, Leka AU - Roebiakto, Erfan AU - Dewi Dwiyanti, Ratih AU - , Rifqoh AU - Rossari, Dhania AU - Tiara Raniesty, Ayu 
JO  - Journal of Engineering and Applied Sciences
VL  - 14
IS  - 22
SP  - 8420
EP  - 8424
PY  - 2019
DA  - 2001/08/19
SN  - 1816-949x
DO  - jeasci.2019.8420.8424
UR  - https://makhillpublications.co/view-article.php?doi=jeasci.2019.8420.8424
KW  - Trichophyton mentagrophytes
KW  -Trichophyton rubrum
KW  -Allium sativum L.
KW  -Candida albicans and Candida tropicalis antifungals
AB  - Treatment of <em>Trichophyton </em>sp. and <em>Candida</em> sp. infections can do with various antifungal drugs, one
of which is <i>Allium sativum</i> L. This herb contains Allicin, flavonoids, tannins, saponins and essential oils that
function as antifungals. The research objective was to compare the effectiveness of <i>Allium sativum</i> L. ethanol
extract on the growth of <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>, <i>Candida albicans</i> and <i>Candida tropicalis</i>. Type of experimental research with the design of the post-test only control group design. The
independent variable was the concentration of ethanol extract of <i>Allium sativum</i> L. and the dependent variable
growth of <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>, <i>Candida albicans</i> and <i>Candida tropicalis</i>.
The statistical test used was Mann-Whitney. Antifungal activity test was carried out by liquid dilution method
with a concentration of 2.5, 5, 7.5, 10, 12.5, 14, 15, 16, 17.5, 18, 20, 22, 24, 26 and 28 mg/mL the results showed
that Minimum Inhibitory Concentration (MIC) against <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>,
<i>Candida albicans</i> and <i>Candida tropicalis</i> were 17.5, 5, 16 and 20 mg/mL Minimum Bactericidal Concentration
(MBC) results against <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>, <i>Candida albicans</i> and <i>Candida tropicalis</i> are 20, 7.5, 18 and 22 mg/mL. Based on the Mann-Whitney <i>Trichophyton rubrum</i> and Trichophyton
mentagrophytes test, a synergistic value of 0.037 (p&lt;0.05) obtained at a concentration of 7.5 mg/mL up
to 15 mg/mL. <i>Candida albicans</i> and <i>Candida tropicalis</i> a significance value of 0.037 (p&lt;0.05) at a
concentration of 18 mg/mL.
ER  -