TY  - JOUR
T1  - Effect of Fish Scale Hydrolysed Collagen on Stability of Water-in-Virgin
Coconut Oil Emulsion for Potential Topical Application
AU - Zainol, Ismail AU - Che Razali, HasnorIzzati AU - Wan Mahamod, Wan Rusmawati AU - Hanim Mat Zain, Haniza AU - Abu Bakar, Norlaili AU - Anuar Alwi, Mohd AU - Jamil, Norlizah 
JO  - Journal of Engineering and Applied Sciences
VL  - 14
IS  - 20
SP  - 7647
EP  - 7655
PY  - 2019
DA  - 2001/08/19
SN  - 1816-949x
DO  - jeasci.2019.7647.7655
UR  - https://makhillpublications.co/view-article.php?doi=jeasci.2019.7647.7655
KW  - Emulsion
KW  -high shear homogenization
KW  -hydrolysed collagen
KW  -stability
KW  -topical application
KW  -transdermal penetration
AB  - Hydrolysed collagen intake has been shown to have a positive effect on flexibility and elasticity of
the skin. However, topical use of hydrolysed collagen in emulsion form is under-explored. The aim of this study
was to investigate the effect of hydrolysed collagen existence on the physical stability and droplet size of
different formulations of water-in-virgin coconut oil emulsion. The obtained emulsion via. high shear
homogenization, both before and after incorporated with hydrolysed collagen showed good physical stability
with no separation layersand suitable to be administered on skin. Incorporating hydrolysed collagen caused
a small additional decrease in emulsion droplet size compared to typical emulsion. The dispersion of small
water-based hydrolysed collagen droplets in emulsion plays an important role for a better permeation of
hydrolysed collagen into the skin, once it applied topically. The rheological properties of emulsion attribute to
shear thinning behaviour which is appropriate for the needs in the topical application. The results recommend
an emulsion system as an innovative approach for enhancing the transdermal penetration of hydrolysed
collagen into skin for topical application.
ER  -