TY  - JOUR
T1  - Characterization of Genipin-Crosslinked Gelatin Hydrogel Loaded with Curcumin
AU - Mohd Nadzir, Masrina AU - Sin Mun, Lau AU - Pei Juan, Chan 
JO  - Journal of Engineering and Applied Sciences
VL  - 12
IS  - 9
SP  - 2294
EP  - 2298
PY  - 2017
DA  - 2001/08/19
SN  - 1816-949x
DO  - jeasci.2017.2294.2298
UR  - https://makhillpublications.co/view-article.php?doi=jeasci.2017.2294.2298
KW  - Gelatin hydrogel
KW  -genipin
KW  -curcumin
KW  -crosslinking
KW  -biomedical applications
AB  - Gelatin hydrogels are attractive for use in biomedical applications due to its well defined structural,
physical and chemical properties. This study aimed to evaluate the physicochemical properties of crosslinked
gelatin hydrogel incorporated with curcumin and the release characteristic of curcumin from the hydrogel matrix.
The addition of naturally occurring crosslinking agent, genipin has improved the mechanical strength of the
gelatin hydrogel. Low concentration of genipin (0.1% w/w) added to gelatin solution prior to solidification
resulted in average pore size more than 1000% larger than the average pore size of un-crosslinked gelatin
hydrogel. However, average pore size was reduced with further increased in genipin concentration. This is
accompanied with decreased in swelling capacity of hydrogel. Curcumin entrapment and release analysis
confirmed that the alteration of pore size through crosslinking with varying genipin concentration enabled the
controlled release of curcumin from hydrogel matrix.
ER  -