TY  - JOUR
T1  - Molecular Characterization, Alternation Splicing, Expression Profile and Association Analysis with Carcass Traits of the Cattle <I>CMYA1</I> 
  Gene
AU - Nie, Y.W. AU - Ding, X.B. AU - Liu, X.F. AU - Ge, X.G. AU - Li, J.Y. AU - Yang, F.F. AU - Guo, T. AU - Guo, H. 
JO  - Agricultural Journal
VL  - 8
IS  - 6
SP  - 276
EP  - 281
PY  - 2013
DA  - 2001/08/19
SN  - 1816-9155
DO  - aj.2013.276.281
UR  - https://makhillpublications.co/view-article.php?doi=aj.2013.276.281
KW  - Association analysis
KW  -cattle
KW  -CMYA1
KW  -single nucleotide polymorphism
KW  -alternation splicing
AB  - The Cardiomyopathy Associated protein 1 (CMYA1) is a actin 
  binding protein which plays an important role in cardiac morphogenesis. In this 
  study, researchers obtained the 6,272 bp mRNA sequence of the cattle <I>CMYA1</I> 
  gene, including the full coding region and encoding a protein of 1,820 amino 
  acids. The sequence was deposited into the GenBank nucleotide database (HQ111436.1). 
  The human (NM_194293) and mice (NM_011724) homologues have a 77.31 and 82.23% 
  identity with the cattle <I>CMYA1</I> gene, respectively. Tissue expression 
  analysis showed that the cattle <I>CMYA1</I> gene was expressed exclusively 
  in striated muscle tissue. Moreover, one deletion variant lacking 382 bp from 
  exon 2 was detected by RT-PCR. Two synonymous SNP rs110346467 and SNP rs110575295 
  in the exon 2 detected, as restriction fragment length polymorphism showed genotype 
  frequencies among 120 crossbred cattle. Association analysis showed that a SNP 
  rs110575295 was significantly associated with the intermuscular fat percentage 
  between 12th and 13th ribs (p&lt;0.05). This study will lay the groundwork for 
  the further investigations on the detailed function of CMYA1 in cattle models.
ER  -