TY - JOUR T1 - Increased Risk and Severity of Pre-Eclampsia among Peri-Urban Women in Kinshasa Province, Democratic Republic of Congo: The Role of Nutritional Transition, Obesity and Dyslipidemia AU - Adeniyi, Oladele Vincent AU - Businge, Charles Bitamazire AU - Longo-Mbenza, Benjamin AU - Babeki, Victor Nzuzi AU - Kaboka, Achille Kitambala AU - Muaka, Moise Mvitu AU - Nkanga, Mireille Solange Nganga AU - Tsobo, Christophe Masiala AU - Vangu, Roland AU - Diambu, Emmanuel Mabiala AU - Goon, Daniel Ter JO - International Journal of Tropical Medicine VL - 12 IS - 3 SP - 29 EP - 34 PY - 2017 DA - 2001/08/19 SN - 1816-3319 DO - ijtmed.2017.29.34 UR - https://makhillpublications.co/view-article.php?doi=ijtmed.2017.29.34 KW - Cardiovascular diseases KW -dyslipidaemia KW -obesity KW -pre-eclampsia KW -Democratic Republic of Congo KW -population AB - This study assessed the risk and severity of pre-eclampsia associated with obesity and dyslipidemia in a peri-urban population of Kinshasa Province, Democratic Republic of Congo (DRC). This case control study recruited 200 participants with preeclampsia as cases and 150 age-matched pregnant women without preeclampsia as controls at the LOMO Medical Centre, Kinshasa. Waist circumference, systolic and diastolic blood pressure, carotid intima-media thickness, serum lipids, C-peptide and Homeostasis-Insulin Resistance Index (HOMA-IR) were measured. There was a significant positive correlation between preeclampsia severity and most markers of metabolic syndrome with biologic gradient. The means±SD for controls, participants with mild and severe pre-eclampsia, respectively were: BMI (kg/m2) 22.2±5.5, 24.1±5.7 and 25.6±6.0, p<0.0001; Total cholesterol (mg/dL) 105.0±56.8, 153.6±63.1 and 173.3±60.1, p<0.0001; LDC (mg/dL) 107.3±3.4, 112.2±4.7 and 122.6±3.5, p = 0.006; TNF-α (ng/L)101.8±4.8, 103.1±6.6, 137.7±5.2 p<0.0001; HOMA-IR (mg/dL) 7.3±0.9, 8.3±1.1 and 11.3±0.7, p<0.0001. There was a negative correlation between pre-eclampsia severity and HDL (mean±SD mg/dL) controls: 41.5±3.2, mild pre-eclampsia: 42.4±4.7 and severe pre-eclampsia: 29.4±2.4, p = 0.003. High BMI increases the risk and severity of pre-eclampsia which may increase the risk of subsequent chronic cardio-metabolic diseases in the mothers. Contrary to other studies, LDL was elevated among pre-eclampsia women in the study population. ER -