TY  - JOUR
T1  - Glucose-6-Phosphate Dehydrogenase Deficiency and Coronary Artery Disease
AU - Seyedian, Seyed Masood AU - Ahmadi, Farzaneh AU - Ghorbani, Parvin AU - Hassan Adeland, Seyed Mohammah AU - Aletayeb, Seyed Mohammah Hassan 
JO  - International Journal of Tropical Medicine
VL  - 11
IS  - 5
SP  - 186
EP  - 188
PY  - 2016
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2016.186.188
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2016.186.188
KW  - G6PD deficiency
KW  -coronary artery disease
KW  -cholesterol
KW  -X-recessive
KW  -LDL
AB  - Glucose-6-phosphatase dehydrogenase (G6PD) deficiency is the most common enzyme deficiency
in humans, affecting 400 million people worldwide. It is inherited as an X-recessive linked disorder. Evidence
indicates that G6PD-deficient patients are protected against cardiovascular disease. Thus we decided to test
this hypothesis in male subjects expressing the G6PD deficiency phenotyp. We evaluated 420 man patients with
CoronaryAartery Disease (CAD) admitted for angiography in Ahvaz Golestan Hospital. The G6PD phenotype
was determined using fluorescent spot test method. Twenty-eight out of 420 (6.7%) patients were G6PD
deficient. In addition, the frequency of dyslipidemia in patients with G6PD deficiency was lower than patients
with normal enzyme activity (p<0.05). Our findings confirmed the hypothesis that susceptibility to CAD in
G6PD-deficient patients is less. We suggest that protective efect may reduce LDL and total cholesterol level
by inhibiting of cholesterol biosynthesis.
ER  -