TY  - JOUR
T1  - <I>Clostridium difficile</I> Toxin in Adult Inpatients in an Urban Hospital 
  in Malawi: Associations with HIV Status, CD4 Count and Diarrhoea
AU - Beadsworth, Michael B.J. AU - Beeching, Nick J. AU - Watson, Alastair AU - Roberts, Paul Paul AU - Farragher, Brian AU - Keeley, Alex J. 
JO  - International Journal of Tropical Medicine
VL  - 9
IS  - 1
SP  - 7
EP  - 9
PY  - 2014
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2014.7.9
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2014.7.9
KW  - sub-Saharan Africa
KW  -Clostridum difficile
KW  -HIV
KW  -diarrhoea
KW  -CDI
AB  - <I>Clostridium difficile</I> Infection (CDI) is the 
  cause of substantial morbidity and mortality in the developed world. However, 
  very little is known about the burden of CDI in sub-Saharan Africa where less 
  antibiotic restriction, high HIV prevalence and greater impact from nosocomial 
  infection mean the potential for a significant disease burden is great. Researchers 
  investigated the prevalence of <I>Clostridium difficile</I> Toxin (CDT), assessing 
  association with HIV, CD4 count and diarrhoea in medical in-patients in Malawi. 
  In 206 patients tested for CDT, 28 (13.6%) were positive. No significant associations 
  were seen with either diarrhoea or HIV. There was a non-statistically significant 
  (p = 0.056) association between CD4 counts of &lt;50 and CDT. The frequency 
  and the clinical implications of CDI in both HIV positive and negative patients 
  in sub-Saharan Africa, requires further assessment.
ER  -