TY  - JOUR
T1  - Protective Properties of Tofu (Curdled Soymilk) Against Acetaminophen-Induced Oxidative Stress in Rats
AU - Ndatsu, Yakubu AU - Olekan, Amuzat Aliyu 
JO  - International Journal of Tropical Medicine
VL  - 8
IS  - 3
SP  - 62
EP  - 67
PY  - 2013
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2013.62.67
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2013.62.67
KW  - Antioxidant
KW  -acetaminophen
KW  -coagulants
KW  -oxidative stress
KW  -tofu
AB  - The study was designed to assess the effect of various coagulants 
  on the protective properties of tofu against acetaminophen induced oxidative 
  stress. Tofu was prepared using different coagulants (calcium salt, alum and 
  steep water (effluent of pap produced from maize). The protective ability of 
  tofu was assessed by treating acetaminophen (50 mg/rat/day) stressed rats with 
  the tofu and water <I>ad libitum</I> for 2 weeks. Oral administration of rats 
  fed basal diet with mega dose of paracetamol (50 mg/100 g) caused a significant 
  decrease in the total feed intake (141.8&plusmn;5.31 g/rats/days), total weight 
  gain (9.1&plusmn;1.35 g/rats/days), PCV (33&plusmn;2.60 g L<SUP>-1</SUP>), Hb 
  (10.9&plusmn;1.48 g L<SUP>-1</SUP>), RBC (4.1&plusmn;0.91x10<SUP>6</SUP> mm<SUP>2</SUP>), 
  MCV (66.5&plusmn;3.65 fl) and WBC (1900&plusmn;19.49 mm<SUP>3</SUP>) compared 
  with those on the basal diet without paracetamol. However, those rats fed with 
  various coagulated tofu with paracetamol had a significant increase in the PCV 
  (34.0-35.5 g L<SUP>-1</SUP>), Hb (11.3&plusmn;1.50-11.8&plusmn;1.54 g L<SUP>-1</SUP>), 
  RBC (4.2&plusmn;0.92-4.8&plusmn;0.98x10<SUP>2</SUP> mm<SUP>2</SUP>), MCV (70.5&plusmn;3.75-74.8&plusmn;3.87 
  fl), WBC (2000&plusmn;20.00-2800&plusmn;23.66 mm<SUP>3</SUP>) and MCH (9.4&plusmn;1.37-9.8&plusmn;1.40x10<SUP>-12</SUP>), 
  compared to those fed basal diet with paracetamol. Also, a significant increase 
  of the serum ALP (122&plusmn;4.93 mg dL<SUP>-1</SUP>), ALT (31&plusmn;2.49 mg 
  dL<SUP>-1</SUP>) and AST (101&plusmn;4.49 mg dL<SUP>-1</SUP>) were observed 
  in rats fed basal diet with paracetamol, compared to those fed basal diet without 
  paracetamol. While those fed tofu with paracetamol had significantly lower value 
  in serum AST (94&plusmn;4.34-80&plusmn;4.0 mg dL<SUP>-1</SUP>), ALT (30&plusmn;2.45-26&plusmn;2.28 
  mg dL<SUP>-1</SUP>) and ALP (120&plusmn;4.90-1104.70 mg dL<SUP>-1</SUP>) compared 
  to those fed basal diet with paracetamol. Furthermore, a significant increase 
  in the serum cholesterol (172&plusmn;5.87 mg dL<SUP>-1</SUP>), LDL (83&plusmn;4.07 
  mg dL<SUP>-1</SUP>), HDL (89&plusmn;4.22 mg dL<SUP>-1</SUP>) and triglyceride 
  (84.3&plusmn;4.11 mg dL<SUP>-1</SUP>) levels of rats fed basal diet with paracetamol, 
  compared with those fed those fed basal diet without paracetamol while those 
  fed tofu with paracetamol had a significant lower values in serum cholesterol, 
  HDL, LDL and triglyceride, compared to those fed basal diet with paracetamol 
  orally administered.
ER  -