TY  - JOUR
T1  - Risk of Mother to Child Transmision of Hepatitis B among Children
AU - Osazuwa, Favour AU - , Anikwe Haryana Chika 
JO  - International Journal of Tropical Medicine
VL  - 7
IS  - 1
SP  - 34
EP  - 37
PY  - 2012
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2012.34.37
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2012.34.37
KW  - seropositive
KW  -hepatitis B
KW  -HBeAg
KW  -HBsAg
KW  -Vertical transmission
AB  - Mother to child transmission of hepatitis B is now been recognized as a major route of acquisition of hepatitis B infection. This study thus aimed to evaluate the rate of vertical transmission of hepatitis B in a cohort of mothers and their children in Abuja, Nigeria. This study was carried out between May to September 2011 in Abuja, Nigeria. In this cross-sectional study, the prevalence of sero-markers to carrier status of hepatitis B (HBsAg) and disease progression and capacity for infectivity (HBeAg) in paired sera samples of apparently healthy mothers and their children in sub-urban communities of Lugbe and Gwagwalada, federal capital territory, Abuja, Nigeria was investigated. Informed consent was received from parents (Mothers and fathers) to include their children. Only children between 6 months to 3.5 years were included the study. Only subjects positive for HBsAg were screened further for HBeAg. A total of 250 mothers and their 291 children were the study subjects. Overall prevalence of HBsAg in the mothers and children studied were 33 (13.2%) and 20 (6.9%). About 9 (27.7%) mothers who were positive for HBsAg were seropositive for HBeAg. A total of 7 (35.0%) children out of 20 HBsAg seropositive children were positive for HBeAg. The risk of vertical transmission of hepatitis B from mothers to their children was high; 7 (77.7) children out of 9 HBeAg positive mothers were HBeAg positive. All 7 HBeAg positive children were children of HBeAg seropositive mothers making a total percentage of perinatally transmitted hepatitis B to be 77.7%. The risk of vertical transmission of hepatitis B was high. Screening for hepatitis B in pregnant women should be a routine practice in the antenatal clinics so as to institute an early immunization for at risk infants after birth.
ER  -