TY  - JOUR
T1  - Serum Biochemical and Liver Enzymes Changes in Dogs with Single and Conjunct Experimental Infections of <I>Trypanosoma brucei brucei </I>and <I>Ancylostoma 
  caninum</I>
AU - Nwoha, R.I.O. AU - Eze, I.O. AU - Anene, B.M. 
JO  - International Journal of Tropical Medicine
VL  - 7
IS  - 4
SP  - 138
EP  - 142
PY  - 2012
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2012.138.142
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2012.138.142
KW  - single and conjunct infections
KW  -Ancylostoma caninum
KW  -Trypanosoma brucei brucei
KW  -serum biochemistry
KW  -dogs
AB  - The serum biochemical changes in dogs with experimental single 
  and conjunct infections of <I>Trypanosoma brucei </I>and <I>Ancylostoma caninum 
  </I>were studied. Four groups (1-4) of five dogs each were used for the study. 
  Groups 1-3 were infected, respectively with 120 L<SUB>3</SUB> of <I>Ancylostoma 
  caninum</I>, 1.5&times;10<SUP>6</SUP> mL <SUP>-1</SUP> of <I>Trypanosoma brucei brucei 
  </I>(federe strain) only and a combination of<I> Ancylostoma caninum</I> and 
  <I>Trypanosoma brucei brucei</I> while Group 1 served as uninfected control. 
  The results show that the infections produced significant changes in the conjunct 
  infection than the single infections. There was apparently shorter pre-patent 
  period of <I> T. brucei brucei</I> (4-6 days) in the conjunct infection as against 
  6-9 days recorded in the single <I>T. brucei brucei </I>infection. There was 
  also a shorter pre-patent period of 13 days as against 19 days in the single 
  <I>Ancylostoma caninum. </I>There was significant high (p&lt;0.05) Blood Urea 
  Nitrogen (BUN) in the infected Groups compared to the control. Also, the total 
  bilirubin and creatinine values of the infected groups were significantly higher 
  (p&lt;0.05) than the control. However, the creatinine levels of Group 3 were 
  unaffected. The serum activities of Aspartate Aminotransferase (AST) and Alanine 
  Aminotransferase (ALT) in all the infected groups were significantly higher 
  (p&lt;0.05) while the serum Alkaline Phosphatase (ALP) activity was significantly 
  lower (p&lt;0.05) than the control. It was concluded that conjunct infection 
  of dogs with <I>Trypanosoma brucei brucei </I>and <I>Ancylostoma caninum </I>which 
  resulted in marked biochemical alterations can be ancillary to diagnosis and 
  useful in prognosis during such natural infections.
ER  -