TY  - JOUR
T1  - Antioxidant Properties of Methanol Extract of Parquetina Nigrescens in Ulcerated Rats
AU - Aderibigbe, O.R. AU - Odetola, A.A. AU - Oluwole, F.S. AU - Farombi, E.O. AU - Onabanjo, O.O. AU - Jiboku, O.A. 
JO  - International Journal of Tropical Medicine
VL  - 6
IS  - 2
SP  - 25
EP  - 29
PY  - 2011
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2011.25.29
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2011.25.29
KW  - Parquetina nigrescens
KW  -SOD (Superoxide Dismutase)
KW  -CAT (Catalase)
KW  -ethanol
KW  -ulcer
KW  -Nigeria
AB  - <I>Parquetina nigrescens</I> is a plant used in folk medicine in treating gastric ulcer. This study investigated the antioxidant properties of <I>P. nigrescens</I> in ethanol ulcerated rats. Rats were pretreated for 7 or 14 days with graded doses (500 and 1000 mg kg<SUP>-1</SUP>) of methanol extract of <I>P. nigrescens</I> before ulcer was induced on 8th or 15th day with absolute ethanol (1 mL/rat). The antioxidant properties of <I>P. nigrescens</I> were assessed using standard procedures. Intoxication with ethanol caused increased lipid peroxidation, reduced activities of Super Oxide Dismutase (SOD) and Catalase (CAT) and reduced protein concentration. Pretreatment with <I>P. nigrescens</I>, however, lowered lipid peroxidation, caused increases in activities of SOD, CAT and protein levels. This study therefore, shows that <I>P. nigrescens</I> possesses antioxidant properties that can protect against free radical induced ulcer.
ER  -