TY  - JOUR
T1  - Comparative <I>in vitro </I>Activity of Some Macrolide (Erythromycin, Clarithromycin and Azithromycin) and Fluoroquinolone (Ciprofloxacin and Ofloxacin) Antibiotics Against <I>Bacillus anthracis</I>
AU - , J. Ngbede AU - , E.B. Ogundeji AU - , D.A. Nyam AU - , R.E.J. Guktur 
JO  - International Journal of Tropical Medicine
VL  - 3
IS  - 2
SP  - 36
EP  - 39
PY  - 2008
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2008.36.39
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2008.36.39
KW  - Fluroquinolones
KW  -macrolides
KW  -B. anthracis
KW  -in vitro activity
KW  -antibiotics
AB  - <I>In vitro</I> activity of three members of the macrolide group of antibiotics (Erythromycin, Clarithromycin and Azithromycin) and two members of the fluoroquinolone group of antibiotics (Ciprofloxacin and Ofloxacin) were  assessed  against <I> Bacillus  anthracis</I>  by  standard  tube  dilution  method.  All  the  isolates  showed varied  susceptibility  to  the  2  groups  of  antimicrobial  agents.  The  isolates  were  susceptible  to Ciprofloxacin (MIC<SUB>50</SUB>-0.78 µg mL <SUP>1</SUP>) and Ofloxacin (MIC<SUB>50</SUB>-0.31 µg mL <SUP>1</SUP>) but were resistant to Erythromycin ((MIC<SUB>50</SUB>-25 µg mL <SUP>1</SUP>), Clarithromycin ((MIC<SUB>50</SUB>-31.25 µg mL <SUP>1</SUP>) and Azithromycin ((MIC<SUB>50</SUB>-200 µg mL <SUP>1</SUP>). Comparing the results  of  the  2  groups  of  antibiotic  susceptibility  tests,  we do not recommend the use of any of the 3 macrolide antibiotics tested for prophylaxis or therapy of <I>B. anthracis </I>in our geographical area, except with specific result of susceptibility test on the particular isolate(s). Ofloxacin is highly recommended as a good alternative to ciprofloxacin antibiotic.
ER  -