TY  - JOUR
T1  - Therapeutic Effect of <I>Aristolochia bractealata</I> Extract Against Experimental <I>Trypanosoma evansi</I> Infection
AU - , H.A.R. Samia AU - , K.H. Elmalik AU - , H.S. Khalid 
JO  - International Journal of Tropical Medicine
VL  - 1
IS  - 4
SP  - 170
EP  - 172
PY  - 2006
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2006.170.172
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2006.170.172
KW  - Aristolocjia
KW  -infection rats
KW  -cholorofomic
KW  -typanocidal
AB  - <I>Aristolochia bracteolata</I> of the family Aristolochiaceae, which was reported in the treatment of malaria and sleeping sickness, was evaluated for its <I>in vivo</I> activity against <I>Trypanosoma evansi</I> infection in rats.  Six groups of 10 rats each aged 5-7 weeks, average weight 150 grams were used.  The plant extract was administered orally at dose rates of 250 and 500 mg kg<SUP>-1</SUP> BW for both the chloroformic and methanolic extract.  The activity was compared to Cymelarsan which was given at a dose rate of 2.5 mg kg<SUP>-1</SUP> BW subcutanously.  Results showed that the plant extract gave a promising trypansocidal effect.  The chloroformic extract gave better result than that of the methanolic extract with both doses.  Its use as a new trypanocidal preparation needs further work to identify the bio-active agent(s).
ER  -