TY  - JOUR
T1  - Effect of Concentration on the Rate of Killing of Some Microorganisms and Haemolytic Activity of Two Varieties of <I>Acalypha wilkesiana</I>
AU - , M.K. Oladunmoye 
JO  - International Journal of Tropical Medicine
VL  - 1
IS  - 3
SP  - 130
EP  - 133
PY  - 2006
DA  - 2001/08/19
SN  - 1816-3319
DO  - ijtmed.2006.130.133
UR  - https://makhillpublications.co/view-article.php?doi=ijtmed.2006.130.133
KW  - Acalypha wilkesiana
KW  -killing rate
KW  -haemolysis
AB  - The effect of concentration change on the rate of killing of some selected microorganisms by ethanolic extracts from two varieties of Acalypha <I>wilkesiana</I> was carried out using the plate count technique. The haemolytic activities by the agar diffusion method was investigated.The killing rate  was found to increase as concentration increases. This was shown by reduction in the amount of survivors in cfu mL<SUP> 1</SUP> as the exposure time progresses. The rate of killing of the microbial population by the extract was also found to be concentration dependent as increase in concentration lead to reduction in microbial loads. The relationship was established to be exponential one as revealed by the concentration queficent The two varieties of the <I>Acalypha</I> <I>wilkesiana</I> also differ in the ability to kill the different bacteria species and fungus (<I>Candid</I>a <I>albicans</I>) with the macrophylla showing higher degree of killing than the Hoffmanin. Generally, the rate of killing was found to vary among the different bacteria species with gram negative ones like <I>Escherichia coli</I>, <I>Klebsiella</I> and <I>Pseudomonas</I> being killed at a lower rate than the gram positive organism like <I>Bacillus</I> and <I>Staphylococcus.</I> <I>Candida albicans</I> being a fungus was killed at extremely lower rate than the bacteria. The haemolytic activity was found to be higher in Macrophylla than Hoffmanin and the values increase as the concentration increases.
ER  -