TY  - JOUR
T1  - Development of Low Dose Eszopiclone Drug Formulation by Using Geometric Blending
Method
AU - Kol, Kübra AU - Toprak, Cüneyt AU - Gün, Gökay 
JO  - Research Journal of Pharmacology
VL  - 14
IS  - 3
SP  - 44
EP  - 48
PY  - 2020
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2020.44.48
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2020.44.48
KW  - Geometric blending
KW  -low-dose active ingredients
KW  -homogeneous distribution
KW  -Eszopiclone
KW  -insomnia
AB  - Eszopiclone is a type of medicine used in the
treatment of insomnia with a hypnotic effect. The aim of
this study is to create Eszopiclone 3 mg tablet formulation
by providing homogeneous distribution of Eszopiclone
raw material which is found in low amount in the drug,
into the Excipients. In order to achieve homogeneous
blending, 4 trial production and pilot studies were carried
out using the geometric blending and elimination method.
Trial 4 was optimized and the process validation study
was approved. Acceptable content uniformity values of
trial 4 and pilot study were calculated as 8.63 and 8.74%,
respectively. In this study, the importance of geometric
blending and elimination method is shown.
ER  -