TY  - JOUR
T1  - Antidiarrheal Potentiality of Methanolic Extract of Different Parts of <I>Musa 
  sapientum</I> Fruits
AU - Ekramul Haque, Md. AU - Zamiul Rashid, S.M. AU - Mominul Islam, M. AU - Sajid, Irfan AU - Kumar Karmaker, Bijan 
JO  - Research Journal of Pharmacology
VL  - 7
IS  - 4
SP  - 41
EP  - 47
PY  - 2013
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2013.41.47
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2013.41.47
KW  - Musa sapientum
KW  -diarrhea
KW  -flavonoid
KW  -antibacterial
KW  -mice
AB  - To investigate the antidiarrheal activities of the methanolic extract of peel (MSPL) and pulp (MSPP) of <I>Musa sapientum</I> fruits, the extract was studied for antidiarrheal property using castor oil and magnesium sulphate induced diarrheal model and charcoal induced gastrointestinal motility as well as PGE<SUB>2</SUB>-induced enterolooping test in mice. In addition, activities against some causative diarrheal pathogenic bacteria were also determined. At the doses of 100 and 200 mg kg<SUP>-1</SUP> body weight, both extracts significantly reduced the frequency and severity of diarrhea in test animals throughout the study period. Both extracts also showed a significant (p&lt;0.001, 0.05) reduction in the gastrointestinal motility in charcoal meal test, as well as PGE<SUB>2</SUB>-induced intrafluid accumulation. MSPL extract also displayed strong antibacterial effect against against <I>Staphylococcus aureus</I>, <I>Salmonella typhi</I>, <I>Shigella dysenteriae</I> and <I>Escherichia coli</I>. Altogether, these results suggest that the <I>Musa sapientum</I> fruit extracts could be used as a potential antidiarrheal agent.
ER  -