TY  - JOUR
T1  - Effect of Paracetamol (Acetaminophen) on Haematological and Reproductive Parameters in Male Albino Rats
AU - Oyedeji, K.O. AU - Bolarinwa, A.F. AU - Ojeniran, S.S. 
JO  - Research Journal of Pharmacology
VL  - 7
IS  - 2
SP  - 21
EP  - 25
PY  - 2013
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2013.21.25
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2013.21.25
KW  - Paracetamol
KW  -Albino rats
KW  -red blood count
KW  -total white blood count
KW  -sperm motility
AB  - Paracetamol (Acetaminophen) is a widely used over the counter analgesic and antipyretic drugs. Several studies have reported the toxic, gastrointestinal and musculoskeletal effect of this drug but there is scanty information on its effect on blood chemistry and reproduction in Albino rats. This study was designed to investigate the effect of this drug on haematological and reproductive parameters in male Albino rats. Paracetamol (7.5 mg kg<SUP>-1</SUP> BW) was administered to the rats for 42 days (6 weeks) for haematological and andrological study. Distilled water (0.5 mL) served as control. Red Blood Cell (RBC) and Total White Blood Cell (TWBC) counts were determined using haemocytometer. PCV was determined by micro-haematocrit method. Semen analyses were done microscopically. Data were analysed using student&#146;s t-test at p&lt;0.05. Treatment of rats with paracetamol caused decrease in PCV and RBC counts relative to the controls. Treatment of rats with paracetamol also caused significant decrease in sperm motility and sperm count but did not produce any pathological lesions on the testes.
ER  -