TY  - JOUR
T1  - Antioxidant, Analgesic and Anti-Inflammatory Activities of <I>Nymphaea Nouchali</I> Flowers
AU - Haque, M. Ekramul AU - Hossen, M. Atowar AU - Mamun, M. Abdullah A. AU - Jahan, Ishrat AU - Sakir, J.A.M. Samir AU - Shamimuzzaman, M. AU - Uddin, M. Jashim 
JO  - Research Journal of Pharmacology
VL  - 6
IS  - 5
SP  - 62
EP  - 70
PY  - 2012
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2012.62.70
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2012.62.70
KW  - Antioxidant
KW  -analgesic
KW  -anti-inflammatory
KW  -Nymphaea nouchali
KW  -DPPH
KW  -Bangladesh
AB  - <I>Nymphaea nouchali </I>leaves are used in folk medicine for the treatment of various disorders. In order to evaluate the actions of this plant, studies were performed on antioxidant, analgesic and anti-inflammatory activities. The Methanolic extract of <I>Nymphaea Nouchali</I> Flowers (MNNF) was evaluated for anti-inflammatory activity using carrageenan induced hind paw edema model whereas hot plate, writhing and formalin tests was carried out for analgesic activity. Total phenolic and flavonoids content, scavenging of 1, 1-Diphenyl-2- Picrylhydrazyl (DPPH) radical, peroxynitrate (ONOO<SUP>-</SUP>) as well as inhibition of total ROS generation were used to evaluate antioxidant potential of MNNF. The extract MNNF at the dose of 100 and 200 mg kg<SUP>-1</SUP>, produced a significant (p&lt;0.05) increase in pain threshold in hot plate method whereas significantly (p&lt;0.05) reduced the writhing caused by acetic acid and the number of licks induced by formalin in a dose dependent manner. The same ranges of doses of MNNF caused significant (p&lt;0.05) inhibition of carrageenan induced paw edema after 4 h in a dose dependent manner. In DPPH, ONOO<SUP>-</SUP> and total ROS scavenging method, MNNF showed good antioxidant potentiality with the IC<SUB>50</SUB> value of 10.33&plusmn;1.02, 20.16&plusmn;0.61 and 31.72&plusmn;0.48 &#956;g mL<SUP>-1</SUP>, respectively. The findings of the study suggested that <I> Nymphaea nouchali </I> has strong analgesic, anti-inflammatory and antioxidant effects, conforming the traditional use of this plant for inflammatory pain alleviation to its antioxidant potentiality.
ER  -