TY  - JOUR
T1  - Anti-microbial Activity and Biochemical Constituents of Two Edible and Medicinal Mushrooms of Mid-Western, Uganda
AU - Nakalembe, Immaculate AU - David Kabasa, John 
JO  - Research Journal of Pharmacology
VL  - 6
IS  - 1
SP  - 4
EP  - 11
PY  - 2012
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2012.4.11
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2012.4.11
KW  - Fractions
KW  -anti-microbial compounds
KW  -Termitomyces sp.
KW  -bioactive
KW  -bacteria
KW  -Uganda
AB  - As a contribution to a search of alternative drugs against emerging resistant pathogenic strains, this study aimed at determination of anti-microbial activity and identification of the potential bioactive compounds in two medicinal mushrooms (<I>Termitomyces</I> sp. (Bunyanaka) and <I>Termitomyces microcarpus</I>) used for treating coughs, boils, sore throat or tonsillitis. To achieve this target, the fractions were obtained from petroleum ether and methanol crude extracts and tested <I>in vitro</I> for anti-microbial activities against selected bacterial strains and a fungus. The bioactive compounds were identified using GC-MS. Gram positive bacteria were more sensitive than gram negative ones. Isolated fractions had activity at a MIC value of 3.13-200 &#956;g mL<SUP>-1</SUP>. Similarly, petroleum ether fractions had high activity than methanol ones. Interestingly, <I>Pseudomonas aeruginosa</I> was more sensitive to <I>Termitomyces</I> sp. fractions with a MIC value of 50-75 &#956;g mL<SUP>-1</SUP>. Several bioactive compounds were identified in the mushrooms. Further studies should be done to elucidate these compounds as a contribution towards drug development.
ER  -