TY  - JOUR
T1  - Hexaconazole Induced Changes in the Histological Architecture of Male and Female Reproductive Systems in Rats
AU - Manohar, B. Murali AU - Sriram, P. AU - Kumar, P. Ravi AU - Mathuram, L.N. AU - Selvasubramanian, S. AU - Kanniappan, M. 
JO  - Research Journal of Pharmacology
VL  - 5
IS  - 2
SP  - 9
EP  - 13
PY  - 2011
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2011.9.13
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2011.9.13
KW  - testis
KW  -histopathology
KW  -ovary
KW  -hexaconazole
KW  -Triazoles
KW  -endometrial glands
AB  - Hexaconazole is a triazole fungicide extensively used in agricultural 
  and horticultural practices. The fungicidal action of triazoles is mainly attributed 
  to their ability to inhibit cytochrome P450 dependent enzyme lanosterol 14 α-demethylase. 
  Lanosterol 14 α-demethylase is necessary for the conversion of lanosterol 
  to ergosterol which is an essential component of fungal cell membrane. Cytochromes 
  P450 are ubiquitous heme containing proteins that are found through out the 
  plant and animal kingdom and play a crucial role in the synthesis of steroidal 
  hormones in mammals. Any interference in the synthesis of sex steroidal hormones 
  will obviously affect the reproductive performance. Thus, hexaconazole was studied 
  for its effect on histological architecture of male and female reproductive 
  system in Wistar rats. Male rats were administered hexaconazole per os daily 
  at 0.0, 27.5, 55.0 and 110.0 my kg<SUP>-1</SUP> body weight for 30 and 
  60 days. Female rats were also given hexaconazole at the same dose level but 
  for 30 and 73 days.
ER  -