TY  - JOUR
T1  - Bioavailability and Pharmacokinetics of Ibafloxacin Following Intravenous and Intramuscular Single-Dose Applications in Chickens
AU - Tohamy, M.A. 
JO  - Research Journal of Pharmacology
VL  - 5
IS  - 2
SP  - 22
EP  - 26
PY  - 2011
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2011.22.26
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2011.22.26
KW  - infection
KW  -chickens
KW  -Ibafloxacin
KW  -bioavilability
KW  -pharmacokinetics
KW  -Egypt
AB  - The single-dose pharmacokinetics of ibafloxacin was studied 
  in clinically normal chickens after intravenous and intramuscular administration 
  of 7.5 mg of ibafloxacin kg&oline;<SUP>1</SUP> of body weight. Ibafloxacin concentrations 
  were determined by Microbiological assay method. The distribution and elimination 
  half-lives were 0.261 and 5.87 h, respectively. Steady-state volume of distribution 
  and clearance of ibafloxacin after intravenous administration were 4.09 L kg&oline;<SUP>1</SUP> 
  and 0.519 L kg&oline;<SUP>1</SUP> h&oline;<SUP>1</SUP>, respectively. Following 
  intramuscular administration, ibafloxacin achieved maximum plasma concentration 
  of 1.06 &#956;g mL&oline;<SUP>1</SUP> achieved after maximum time of 1.3 h post-injection. 
  The systemic bioavailability after intramuscular injection was 79.6% and the 
  extent of serum protein binding was 27.04%. Ibafloxacin could be useful in the 
  treatment of systemic infections in chickens after specific assessment of susceptible 
  microorganisms.
ER  -