TY  - JOUR
T1  - Anti-Plasmodial and Larvicidal Effects of Surface Exudates of <I>Gardenia ternifolia</I> Aerial Parts
AU - Okinda Owuor, P. AU - Ogweno Midiwo, J. AU - Ochieng, Charles O. 
JO  - Research Journal of Pharmacology
VL  - 4
IS  - 2
SP  - 45
EP  - 50
PY  - 2010
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2010.45.50
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2010.45.50
KW  - kaempferol-7-O-methylether
KW  -quercetin-4
KW  - 7-O-dimethylether
KW  -naringenin-7-O-methylether
KW  -surface exudates
KW  -Gardenia ternifolia
KW  -anti-plasmadial
KW  -LC50
KW  - IC50
AB  - Various parts of <I>Gardenia ternifolia</I> (leaves, roots and stem bark) have been reported by traditional healers as a remedy against malaria fever. The aerial parts are coated with shiny materials rich in flavonoid aglycones. The crude acetone wash of the aerial parts showed anti-plasmodial activity of IC<SUB>50</SUB> values 1.06 and 0.94 &#956;g mL<SUP>-1</SUP> against chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of <I>Plasmodium falciparum</I>, respectively. Bioassay guided chromatographic separation of the crude extracts afforded five flavonoids; (naringenin-7-O-methylether, quercetin-4, 7-O-dimethylether, kaempferol-7-O-methylether, 4, 5-Dihydroxy-6, 7-dimethoxyflavanone, naringenin-4, 7-O-dimethyl-ether) and two steroids; (stigmasterol, &#946;-sitosterol). The same crude acetone surface extract as well as the pure isolates showed moderate larvicidal effects against 2nd instar <I>Ae. aegypti</I> larvae. Naringenin-7-O-methyl-ether was the most potent principle.
ER  -