TY  - JOUR
T1  - Comparative <I>in vitro</I> Study of Relative Anesthetic Potency of Ropivacaine and Lidocaine
AU - Charisi, Marilena AU - Liverdos, Kyriakos AU - Dabarakis, Nikolaos AU - Karanikola, Theodora AU - Tsirlis, Anastasios 
JO  - Research Journal of Pharmacology
VL  - 4
IS  - 1
SP  - 1
EP  - 4
PY  - 2010
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2010.1.4
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2010.1.4
KW  - sciatic nerve
KW  -in vitro
KW  -comparative study
KW  -ropivacaine
KW  -Lidocaine
KW  -compound action potentials
AB  - The purpose of this experimental study was the accurate evaluation of relative anesthetic potency of lidocaine and ropivacaine electrophysiologically <I>in vitro</I>. Total 18 sciatic nerves from male Wistar rats weighing between 250-300 g were used. The sciatic nerves were dissected from the spinal cord to the knee, immersed in a standard saline solution and mounted across a three-chambered recording bath. The 18 nerves were divided in 2 groups. In group A 300 &#956;L of ropivacaine 0.2% and in group B 300 &#956;L of lidocaine 0.2% were applied. Each local anesthetic remained in the perfusion chamber until the reduction of the compound action potential reach the 50% of the originally measured value (IT<SUB>50</SUB>) and this reduction was accepted as establishment of anesthesia. Ropivacaine 0.2% was proved to be of statistically less potency regarding the establishment of anesthesia compared to lidocaine 0.2% (p = 0.000497) in the pH of 7.4. The IT<SUB>50</SUB> for the nerves, which came in direct contact with ropivacaine 0.2% was estimated to be 25.28&plusmn;7.61 min (n = 9). As for lidocaine 0.2% the IT50 was estimated to be 11.78&plusmn;4.18.
ER  -