TY  - JOUR
T1  - Selective <I>In vitro </I>Cytotoxic Effects of Piroxicam and Mefenamic Acid on Several Cancer Cells Lines
AU - , M.N. Somchit AU - , S. Faizah AU - , A. Zuraini AU - , H.M. Khairi AU - , A.H. Hasiah AU - , Z.A. Zakaria 
JO  - Research Journal of Pharmacology
VL  - 3
IS  - 1
SP  - 15
EP  - 18
PY  - 2009
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2009.15.18
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2009.15.18
KW  - Piroxicam
KW  -mefenamic acid
KW  -cancer
KW  -NSAIDs
KW  -HCT 116
KW  -CaCo-2
AB  - Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are heterogenous group of compounds used to cure and prevent inflammation. It was demonstrated that NSAIDs has the ability to inhibit the viability of colon cancer cells <I>in vitro</I>. We investigated the effects of Piroxicam and mefenamic acid on the viability of 4 cancer cell lines in which 2 of them are colon cancer cell lines (HCT 116 and CaCo-2). Cell viability was determined using MTT assay. Both NSAIDs was observed to markedly decrease  the  cell  viability  of  both  cell  lines (HCT 116 and CaCo-2). Piroxicam was statistically more cytotoxic towards the cancer cell lines when compared to mefenamic acid. However, the cytotoxic effect of NSAIDs was less potent on breast cancer cells (MCF-7) and liver cancer cells (Hep G2).  In conclusion, piroxicam and mefenamic acid showed selective cytotoxic effects against colon cancer cells but not against liver or breast cancer cells.
ER  -