TY  - JOUR
T1  - Antinociceptive and Anti-Inflammatory Effects of <I>Lonicera japonica</I> Thunb
AU - , M.R. Sulaiman AU - , Z.A. Zakaria AU - , S. Moin AU - , M.N. Somchit AU - , Y.S. Chai 
JO  - Research Journal of Pharmacology
VL  - 2
IS  - 3
SP  - 38
EP  - 42
PY  - 2008
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2008.38.42
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2008.38.42
KW  - Lonicera japonica
KW  -flower’s buds
KW  -aqueous extract
KW  -antinociceptive activity
KW  -anti-inflammatory activity
AB  - The present study was carried out to establish the antinociceptive and anti-inflammatory activities of the aqueous extract of <I>Lonicera japonica</I> flowers’ buds in various experimental animal models. The antinociceptive activity was measured using the abdominal constriction, hot plate and formalin tests, while, the anti-inflammatory  was   measured  using  the  carrageenan-induced  paw  edema. The dried flower’s buds of <I>L. japonica </I>was added with distilled water (1:10 w v <SUP>1</SUP>) and boiled for 2 h at 80°C. The supernatant collected was  freeze-dried   overnight   and   prior    to   use  was  diluted to the desired doses. The extract (30, 100 and 300 mg kg<SUP>-1</SUP>; administered intraperitoneally) exhibited significant (p&lt;0.05) antinociceptive and anti-inflammatory activities in all assays used. In conclusion, the flower’s buds of <I> L. japonica </I>possessed potential antinociceptive and anti-inflammatory activities that require further in-depth studies.
ER  -