TY  - JOUR
T1  - Detection of Tylosin Residue Levels Following Intramuscular Injection in Desert Sheep
AU - , Samia A.A. Hassan AU - , Sania A.I. Shaddad AU - , I.B. ElTayeb AU - , M.A. Omer AU - , M.H. Al-Nazawi AU - , A.M. Homeida 
JO  - Research Journal of Pharmacology
VL  - 2
IS  - 1
SP  - 1
EP  - 3
PY  - 2008
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2008.1.3
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2008.1.3
KW  - Residue
KW  -intramuscular
KW  -tylosin
KW  -sheep
AB  - A total of 12 healthy desert sheep were injected intramuscularly with multiple doses of 5 g kg<SUP>-1</SUP> tylosin. Samples were collected at time 1, 3, 7 and 10 days after drug administrations. Tylosin was detected using microbiological method. Tylosin concentrations in different tissue were detected. High concentration of 61.78±5.83,  315.97±73.07  and  3956±645.59  µg g<SUP>-1</SUP> were  detected in liver, kidney and muscle, respectively at day 1. The highest concentrations of 19185±2966.9 µg g<SUP>-1</SUP> were noted at the site of injection at day 1 and persisted for 10 days. Low concentrations of 1.00, 1.5±0.24 and 5.22±0.20 µg g<SUP>-1</SUP> were noted in the liver, kidney and muscle at day 10, respectively. It is suggested that high tissue levels may create a reservoir of drug from which drug was released slowly into the circulation.
ER  -