TY  - JOUR
T1  - <I>In vivo</I> Antiplasmodial Activity and Acute Toxicity of the Fraction of the <I>Garcinia parvifolia</I> Miq. Stem Bark
AU - , Syamsudin AU - , S. Wahyuono AU - , S. Tjokrosonto AU - , Mustofa 
JO  - Research Journal of Pharmacology
VL  - 1
IS  - 4
SP  - 79
EP  - 83
PY  - 2007
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2007.79.83
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2007.79.83
KW  - Antiplasmodial
KW  -acute toxicity
KW  -active fraction
KW  -Garcinia parvifolia Miq
AB  - The study of <I>in vivo</I> antiplasmodial activity and acute toxicity of the active fraction of <I>Garcinia parvifolia</I> Miq has been conducted. The fraction was obtained by maceration of n-hexane extract with methanol. A standard 4-day test on P. berghei infected Swiss mice was used to evaluate the <I>in vivo</I> antiplasmodial activity after an oral administration of  the  fraction  in  series dose of 25-200 mg kg <SUP>1</SUP> BW once daily for 4 consecutive days. The <I>in vivo</I> antiplasmodial  activity  was expressed by the dose inhibiting 50% of parasite growth (ED<SUB>50</SUB>). Acute toxicity was evaluated in Swiss mice after oral administration of the active fraction in series dose of 2000-8000 mg kg <SUP>1</SUP> BW. The acute toxicity was expressed by the dose leading 50% deaths (LD<SUB>50</SUB>). The results showed that the active fraction of <I>G. parvifolia</I> Miq was active against P. berghei in mice with an ED<SUB>50 </SUB>of 74.45 mg/kg BW/d. In addition, the active fraction was also relatively safe as expressed by the LD<SUB>50</SUB> of 8.000 mg kg <SUP>1</SUP> BW.
ER  -