TY  - JOUR
T1  - Effect of Aqueous Methanolic Stem Bark of <I>Maerua angolensis</I> (<I>Capparidaceae</I>) Extract on Blood Glucose Levels of Streptozocin-induced Diabetic Wistar Rats
AU - , A. Mohammed AU - , Y. Tanko AU - , M.A. Okasha AU - , Y. Sadiq AU - , A.I. Isa 
JO  - Research Journal of Pharmacology
VL  - 1
IS  - 4
SP  - 75
EP  - 78
PY  - 2007
DA  - 2001/08/19
SN  - 1815-9362
DO  - rjpharm.2007.75.78
UR  - https://makhillpublications.co/view-article.php?doi=rjpharm.2007.75.78
KW  - Maerua angolensis
KW  -hypoglycemic activity
KW  -streptozocin
KW  -diabetes mellitus
AB  - The hypoglycemic effect of aqueous methanolic extract of <I>Maerua angolensis </I>stem bark was investigated  in  streptozocin-induced  diabetic rats. A single  administration  of the extract at the doses of  250, 500 and 1000 mg kg <SUP>1</SUP>. There was a significant decreased in the blood glucose levels after 4 of extract administration  at  the  doses of  250  and  500  mg  kg <SUP>1</SUP>. Also after  8  and  24  h  of extract administration there was a significant decreased (p&lt;0.05) in the 3  dose administered. The  effective  dose  resides  at  the dose of 500 mg kg <SUP>1</SUP>. The Preliminary phytochemical screening revealed the presence glycosides, tannins, saponins, terpenes, flavonoids, carbohydrate, protein and alkaloids. The median Lethal Dose (LD<SUB>50</SUB>) in rats was calculated to be 3807.8 mg kg <SUP>1</SUP> body  weight.  In  conclusion  the  aqueous  methanolic  extract  of <I> Maerua  angolensis</I>  stem  bark possess anti-diabetic effect in streptozocin induced in diabetic rats.
ER  -