TY  - JOUR
T1  - Comparative Cytotoxic and Anticancer Effect of Taxol Derived from Aspergillus terreus and
Taxus brevifolia
AU - Zein, 1Nabila AU - S. El-Sayed, Ashraf 
JO  - Research Journal of Medical Sciences
VL  - 14
IS  - 2
SP  - 26
EP  - 33
PY  - 2020
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2020.26.33
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2020.26.33
KW  - Aspergillus terreus
KW  -taxol
KW  -Ehrlich ascites
carcinoma
KW  -MMP9
KW  -caspase 3
KW  -apoptosis and
histopathology
AB  - Taxol is a highly oxygenated diterpenoid of
broad spectrum anticancer activity, due it unique
specificity for binding with tubulin β-subunits
heterodimer of tumor cells, disrupting their mitotic
division. Taxol has been commercially produced from
Taxus brevifolia, however, its lower yield, accessibility
and pricey are the current challenges for this technology,
thus, exploring of fungi as alternative source of taxol
could opened new platforms for production of this drug.
From our previous studies, taxol has been produced by
A. terreus with the same chemical structural identity with
that from T. brevifolia. Thus, the objective of this study
was to comparatively evaluate the cytotoxicity and
anticancer activity of Aspergillus Terreus taxol (AT-taxol)
and commercial Taxus Brevifolia taxol (TB-taxol) against
ehrlich ascites carcinoma in female Swiss albino mice via.
intraperitoneal injection. Taxol from both sources had the
same cytotoxic biochemical patterns as well as anticancer
activity against ehrlich ascites carcinoma. Positive control
mice showed an increasing on the serum Nitric Oxide
(NO) and lipid peroxidation (MDA) level accompanied by
a decline in Total Antioxidant Capacity (TAC) in addition
to MMP9 upregulation and caspase-3 down regulation.
Histopathologically, liver and kidney tissues showed
some pathological features due to the oxidative stress
induced by EAC. AT-taxol and TB-taxol gave the same
potent antioxidant and anticancer properties by
augmenting the antioxidant defense system through
induction of apoptosis and protecting both liver and
kidney against oxidative stress induced by ehrlich ascites
carcinoma.
ER  -