TY  - JOUR
T1  - The Possible Link Between Atorvastatin and Cataract inRats:
An Experimental Study
AU - Saad Mohamed, Eman AU - Elawady Ebrahim, Amal AU - Ahmed Aly, Mervat 
JO  - Research Journal of Medical Sciences
VL  - 12
IS  - 1
SP  - 35
EP  - 40
PY  - 2018
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2018.35.40
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2018.35.40
KW  - lens
KW  -rat
KW  -cataract
KW  -Atorvastatin
KW  -proteins
KW  -HDL
AB  - Atorvastatin is a member of drugs known as statins that responsible for lowering lipids to prevent
cardiovascular disease. The purpose of this study is to determine potential cataractogenic action of atorvastatin
in rats. Almost 75 healthy albino Wistar rats were classified into four groups: Group 1 served as
control, Group 2 were animals received hypercholesterolemic diet, Group 3 and 4 that animals received
hypercholesterolemic diet with atorvastatin in two doses 1.14 and 11.4 mg/kg/day, respectively. Activity
of Na+-K+ ATPase was measured in lens membrane. Soluble lens proteins and Refractive Index (RI) were
detected. In addition Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis (SDS-PAGE) was done for
all the studied groups. A significant decrease (p<0.05) were observed in activity of Na+-K+ ATPase in lens
membrane and soluble lens proteins of group 4 that received a high dose of atorvastatin in contrast to all others
groups. There were remarkable shifts in molecular weight of all protein fractions detected in pattern of
SDS-PAGE come with atorvastatin administrated (Group 4). Also, the same phenomena in appearing no
variation in its value of RI to Group 2 or 3 and a significant difference (increase, p<0.05) observed in Group 4.
Lens turned out to be reacted to atorvastatin, especially, high doses administrated.
ER  -