TY  - JOUR
T1  - The Impact of using Botulinum Toxin-A on Urinary Tract
Infection in Patients with Overactive Bladder
AU - Saqan, Rola S. AU - Alaraji, Ameer K. AU - AlAzab, Rami S. AU - Khasawneh, Wasim 
JO  - Research Journal of Medical Sciences
VL  - 11
IS  - 4
SP  - 186
EP  - 190
PY  - 2017
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2017.186.190
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2017.186.190
KW  - Overactive bladder
KW  -botulinum toxin-A
KW  -urinary tract infection
KW  -E. coli
KW  -prophylactic
KW  -antibiotic
AB  - Botulinum toxin-A has been used in the treatment of overactive bladder effectively. The objective
of this study was to investigate the effects of using Botulinum Toxin-A (BoNT-A) in reducing the frequency
of urinary tract infections. The 119 patients were included in this study. A retrospective design was conducted
to collect data from patients who visited urology clinics at King Abdulla University Hospital. Results showed
that the mean age of study participants was 25.80+22.63 years, among them were 35(29.4%) males, 68.1% of
participants had at least one positive urine culture in the 6 months preceding the treatment. Among positive
cultures, E. coli was the most prevalent organism (42.6%) and the rate of mixed growth was about 30%.
Post-treatment urine cultures showed that about 44.5% were positive of which E. coli was the most prevalent
(37%). The rate of mixed growth had increased to about 39.22%. Taken together, our study showed that using
botulinum toxin-A is helpful in reducing urinary tract infection. Furthermore, botulinum toxin-A increased the
frequency of mixed growth and we might speculate that using a prophylactic antibiotic course accompanied
with its use is recommended.
ER  -