TY  - JOUR
T1  - Warfarin Inhibits Tumor Metastasis Through an Immune-Modulatory, Coagulation-Independent Manner That Involves NK Cells: Possible Anti-Tumor Effects in Patients with OSCC?
AU - Dietrich, Eva-Maria 
JO  - Research Journal of Medical Sciences
VL  - 9
IS  - 3
SP  - 64
EP  - 66
PY  - 2015
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2015.64.66
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2015.64.66
KW  - Warfarin
KW  -OSCC
KW  -immune-modulation
KW  -killer-cells
KW  -natural
AB  - Tumor patients show alterations of the clotting mechanism by means of a hypercoagulable state. Warfarin’s anti-tumor action was reported in animal cancer models and in human studies with patients already receiving warfarin. An arrest of lung metastases was reported. The mechanism for this anti-tumor action seems to be coagulation-independent, probably involving immune-modulatory mechanisms related to NK function. It would be of great interest to evaluate the hypothesis that warfarin is able to modulate the generation of lymph-node metastases in OSCC by affecting NK receptors in an immune-modulatory manner.
ER  -