TY  - JOUR
T1  - Comparison of the Anticonvulsant Effect of Flunarizine, Nimodipine and Sodium Valproate
in Rats
AU - Thorat, V.M. AU - M. Bairagi, Jaydeep 
JO  - Research Journal of Medical Sciences
VL  - 9
IS  - 6
SP  - 314
EP  - 318
PY  - 2015
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2015.314.318
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2015.314.318
KW  - Flunarizine
KW  -anticonvulsant
KW  -rat
KW  -sodium valproate
KW  -epilepsy
AB  - The calcium channel blockers flunarizine,
comparing the inhibitory effects of nifedipine and their
efficacy with sodium valproate are induced in MES and
PTZ in broad-spectrum anticonvulsant Alzheimer’s mice.
Calcium ion and its entry play an important role in origin
of seizures. The objective of the study is to investigate
effect of cerebro selective Calcium Channel Blockers
(CCBs), flunarizine and nimodipine with three different
dosages and sodium valproate with one dose on MES
(Maximal Electroshock Seizures) and PTZ
(Pentylenetetrazol) induced convulsions in wistar rats.
The CCBs have established themselves as very effective
therapeutic agents in various disorders of the
cardiovascular system like systemic hypertension,
supraventricular arrhythmias, angina pectoris, etc., in
central nervous system like migraine, vertigo,
subarachnoid hemorrhage, etc. and for reversal of
resistance in chemotherapy. In this study, the pre-clinical
evaluation for anticonvulsant profile of cerebro selective
CCBs viz. Flunarizine and Nimodipine and their
comparison with standard drug sodium valproate using
conventional models of experimental epilepsy, i.e. by
MES and PTZ induced seizures in wistar rats.
ER  -