TY  - JOUR
T1  - The Profiles of Lipid Peroxidation and Anti-Oxidant Activities in Gestational Diabetes Mellitus and Normal Pregnancies in Nigerian Population
AU - O. Adeniji, Adetunji AU - P. Oparinde, Dolapo 
JO  - Research Journal of Medical Sciences
VL  - 7
IS  - 3
SP  - 75
EP  - 79
PY  - 2013
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2013.75.79
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2013.75.79
KW  - Lipid peroxidation
KW  -anti-oxidant status
KW  -gestational diabetes mellitus
KW  -malondialdehyde
KW  -TBA
AB  - To compare the lipid peroxidation and total antioxidant status 
  in women with gestational diabetes mellitus and normal pregnancy in the environment. 
  This was a 2 years, cross sectional case control study of 25 Gestational Diabetes 
  Mellitus (GDM) and 75 matched normal pregnant women at Ladoke Akintola University 
  of Technology (LAUTECH) Teaching Hospital, Osogbo, Nigeria. The study protocol 
  was reviewed and approved by the Institutional Ethical Review Committee and 
  all participants gave their consent. The fasting serum of recruited patients 
  were analysed for lipid peroxidation product Malondialdehyde (MDA) based on 
  MDA reaction with Thiobarbituric Acid (TBA) with rapid, sensitive and specific 
  Thiobarbituric Acid (TBA) assay while the Total Anti-oxidant Status (TAS) was 
  determined using the capacity of the biological fluids to inhibit the production 
  of Thiobarbituric Acid Reactive Substances (TBARS) from sodium benzoate under 
  the influence of the free oxygen radicals derived from Fenton’s reaction. The 
  mean serum MDA was significantly higher in the GDM group (3.64 nmol mL<SUP>-1</SUP>) 
  than the value recorded (1.33 nmol mL<SUP>-1</SUP>) in the control group (p&lt;0.0001). 
  Conversely, significantly lower mean TAS (0.34 vs. 0.66 nmol mL<SUP>-1</SUP>) 
  was noticed in the GDM group (p&lt;0.0001). The study showed significant increase 
  in lipid peroxidation and failure of compensatory antioxidant functions in GDM 
  Nigerian women.
ER  -