TY  - JOUR
T1  - <I>Cassia tora</I> L. Cream Inhibit Ultraviolet B Induced Oxidative Stress in Rats
AU - Singhal, Manmohan AU - Kansara, Niraj 
JO  - Research Journal of Medical Sciences
VL  - 6
IS  - 3
SP  - 145
EP  - 147
PY  - 2012
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2012.145.147
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2012.145.147
KW  - O/W creams
KW  -Oxidative stress
KW  -glutathione
KW  -lipid peroxidation
KW  -antioxidant
AB  - The aim of this study was to determine the <I>in vivo</I> antioxidant activity of newly formulated Oil in Water (O/W) creams of methanolic extract of <I>Cassia tora </I>L. leaves. O/W creams of methanolic extract of <I>Cassia tora </I>L. leaves was prepared, evaluated and tested for acute dermal toxicity study. The different O/W creams showed good physical characteristics and pass the sensitivity, irritation, grittiness and bleeding test. Exposure of Ultraviolet-B (UV-B) light decreased the reduced Glutathione (GSH), Catalase (CAT) and Superoxide Dismutase (SOD) activities and increased the Lipid Peroxidation (LPO). The oxidative stress induced by exposure of UV-B light in rats was minimized by single dose topical application of different concentrations of O/W creams and <I>Cassia tora</I> Methanolic extract (CTM). Researchers concluded that topical O/W creams and methanolic extract of <I>Cassia tora</I> leaves has potent antioxidant activity.
ER  -