TY  - JOUR
T1  - Low Serum Fetuin A Levels and Cardiovascular Events in End-Stage Renal Disease (ESRD) Patients
AU - , Giulia Bivona AU - , Chiara Bellia AU - , Antonietta Caruso AU - , Daniela Butera AU - , Bruna Lo Sasso AU - , Patrizia Altavilla AU - , Rosa C. Carollo AU - , Gaia Chiarello AU - , andMarcello Ciaccio 
JO  - Research Journal of Medical Sciences
VL  - 2
IS  - 4
SP  - 200
EP  - 202
PY  - 2008
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2008.200.202
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2008.200.202
KW  - Fetuin-A
KW  -ESRD
KW  -inflammation
KW  -vascular calcification
KW  -CVD
AB  - The atherosclerotic Cardiovascular Disease (CVD) is frequently observed in End-Stage Renal Disease (ESRD) patients; according to the hypothesis of non-traditional risk factors for CVD, accelerated atherogenesis in these patients could be linked to both vascular calcification and inflammation.  2-Heremans-Schmid Glycoprotein (AHSG) also known as Fetuin-A, is considered a negative marker of inflammation and represents one of the <I>in vivo</I> circulating calcification modulators; these molecules are proteins working as endogenous inhibitors of Ca×PO<SUB>4</SUB> precipitation and are probably involved in the pathogenesis vascular calcification. Aim of this study is to evaluate the differences in serum Fetuin-A levels between 2 Haemodialysis (HD) patient groups distinguished on the basis of history of cardio and/or cerebrovascular events. All patients took part in clinical data collection and 2 patient groups were identified as no cardiovascular and cardiovascular on the basis of history of cardio and/or cerebrovascular events. Serum Fetuin-A levels were determined using sandwich immunoenzymatic assay, ELISA (Epitope Diagnostics Inc., San Diego, CA, USA). Serum Fetuin-A levels were significantly lower in cardiovascular HD patients than in those without cardiovascular event. The role of Fetuin A in the context of the different pathogenetic moments of atherosclerosis remains unclearly assessed; it would be of some interest to investigate the hypothesis, almost unexplored, of a relationship between low Fetuin A levels and endothelial dysfunction.
ER  -