TY  - JOUR
T1  - Plasma Biochemical Parameters as Surrogate Prognostic Markers in HIV-1 Infected Patients
AU - , O.A. Ajose AU - , S.O. Banjoko AU - , O.A. Olasode AU - , V.A. Oyegunle AU - , J.B. Fakunle 
JO  - Research Journal of Medical Sciences
VL  - 2
IS  - 4
SP  - 163
EP  - 165
PY  - 2008
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2008.163.165
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2008.163.165
KW  - HIV-1
KW  -surrogate marker
KW  -prognosis
KW  -markers
KW  -infected patients
AB  - The depression of the immune system accompanied by different metabolic derangements which are worsened by secondary infections are responsible for morbidity and subsequent mortality in HIV-1 infected patients. While, the gold standard prognostic marker for the infection remains the CD4+T lymphocyte count, plasma biochemical markers are potential surrogate prognostic markers. Samples obtained from 100 consecutively diagnosed HIV-1 infected patients who were not on anti retroviral therapy and equal number of apparently healthy seronegative individuals as controls were analysed for urea, creatinine total protein, albumin, globulin and albumin: globulin ratio using kits obtained from Randox laboratorie, U.K. spectrophotometrically and Na+, K+ and HCO<SUB>3</SUB> ions concentration using the ion selective electrode analyzer. obtainable from Hitachi, Japan. Compared to the controls, statistically significant differences were observed in the plasma concentrations of HCO<SUB>3</SUB> (p&lt;0.001) urea (p&lt;0.005) creatinine (p&lt;0.001), total protein (p&lt;0.001), albumin (p&lt;0.0001) globulin (p&lt;0.001) and albumin: Globulin ratio (p&lt;0.0001). However, no significant difference were observed in the Na+ and K+ ion concentrations with p values of 0.10 and 0.25, respectively. Those significantly different plasma biochemical parameters can therefore be useful surrogate prognostic markers for HIV-1 infections in resource limited settings.
ER  -