TY  - JOUR
T1  - Hemophagocytic Lymphohistiocytosis: A Four-Year Experience
AU - , A. Hoseynpour-Feyzi AU - , H.R. Tavakoly AU - , A. Fayyazi AU - , A. Dezhakam AU - , A.G. Behbahan AU - , M. Shhverdi 
JO  - Research Journal of Medical Sciences
VL  - 2
IS  - 3
SP  - 105
EP  - 108
PY  - 2008
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2008.105.108
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2008.105.108
KW  - Hemophagocytosis
KW  -bone marrow
KW  -transplantation
KW  -FFL
KW  -IAHS
AB  - Hemophgocytic lymphohisiocytosis is one of the Histiocytosis subgroup that results from over stimulation of macrophages in tissue. Upon presence of an underlying genetic factor it classified into 2 groups: Familial Erythrophagocytic Syndrome (FEL) and Infection Associated Hemophagocytic Syndrome (IAHS). In our center (Tabriz Children’s Hospital) during recent four years (2002-2006) we finded 5 cases of this disease according to clinical and bone marrow aspiration findings. Four cases were male and one was female. All had hepatosplenomegaly and fever, 4 cases had pancytopenia and 1 last had thrombocytopenia. Four had elevated liver enzymes three were diagnosed as FEL and two as IAHS. Finally, with early diagnosis of disease, we can improve prognosis with pretreatment of chemotherapy, bone marrow transplantation and other supportive cares.
ER  -