TY  - JOUR
T1  - Changes in Some Biochemical Parameters of Kidney Functions in Rats Co-Administered with Chloroquine and Aspirin
AU - , H.U. Nwanjo AU - , N.J.C. Okolie AU - , G. Oze AU - , M.C. Okafor AU - , D. Nwosu AU - , C. Ajero B. Anyaehie AU - , G.C. Uloneme AU - , C.J. Njoku AU - , P. Nwamkpa 
JO  - Research Journal of Medical Sciences
VL  - 1
IS  - 2
SP  - 106
EP  - 109
PY  - 2007
DA  - 2001/08/19
SN  - 1815-9346
DO  - rjmsci.2007.106.109
UR  - https://makhillpublications.co/view-article.php?doi=rjmsci.2007.106.109
KW  - Chloroquine
KW  -aspirin
KW  - co-administration
KW  - kidney function
KW  -biochemical
KW  -parameters
AB  - This study was done to establish the effects of co-administration of chloroquine with aspirin on kidney function. We monitored renal parameters such as urea, creatinine and electrolytes. The experimental animals were divided into 4 groups. Group 1 received only food and water (control). Group 2-4 received in addition to food and water either single dose with aspirin (8 mg kg <SUP>1</SUP> body weight day <SUP>1</SUP>), chloroquine phosphate (5 mg kg <SUP>1</SUP> body weight day <SUP>1</SUP>) or combined therapy of chloroquine and aspirin for 8 days. The chloroquine-treated group showed a significant increase in mean serum urea and creatinine levels (p< 0.05) and significant decrease in mean serum sodium and potassium levels (p< 0.05) when compared with the corresponding  values  of  the  control  group. This study also revealed that co-administration of chloroquine and  aspirin  caused a more pronounced decrease in serum sodium and potassium levels. The results of the study suggest that acute administration of chloroquine may affect kidney function, more so when co-administered with aspirin; two drugs sometimes combined in the treatment of malaria in a malaria endemic country such as Nigeria.
ER  -