TY  - JOUR
T1  - Evaluation of Thyroid Function Tests in Patients with Diabetes Mellitus: A Hospital‐Based Study
AU - Mahli, Rajiv AU - Raghu, Mahto AU - Narety, Pushpendra 
JO  - Research Journal of Medical Sciences
VL  - 19
IS  - 5
SP  - 28
EP  - 33
PY  - 2025
DA  - 2001/08/19
SN  - 1815-9346
DO  - makrjms.2025.5.28.33
UR  - https://makhillpublications.co/view-article.php?doi=makrjms.2025.5.28.33
KW  - Thyroid dysfunction
KW  - type 2 diabetes mellitus
KW  - ELISA
KW  - GOD‐POD method
KW  - metabolic control
KW  - Hazaribag Medical College
AB  - Thyroid hormones are essential regulators of carbohydrate metabolism,
and their imbalance may disproportionately affect individuals with type
2 diabetes mellitus (T2DM). This study aimed to assess the profile of
thyroid function among T2DM patients attending a tertiary care hospital
in Hazaribagh, with the goal of identifying potential hormonal
disturbances that could influence diabetic management. A total of 100
patients diagnosed with T2DM were selected from various clinical
departments‐Medicine, Obstetrics & Gynecology, and Surgery‐at SBMC
,Hazaribagh. Participants were enrolled regardless of age or gender, and
informal consent was obtained prior to inclusion. Fasting and
postprandial blood glucose levels were determined using the Glucose
Oxidase‐Peroxidase (GOD‐POD) method. Serum levels of triiodothyronine
(T3), thyroxine (T4), and thyroid‐stimulating hormone (TSH) were
evaluated using the Enzyme‐Linked Immunosorbent Assay (ELISA)
technique. Additional data were collected on socio‐demographic
variables, duration of diabetes, and anthropometric measurements.
Waisthip ratio (WHR) was computed, and statistical analyses‐including
means, standard deviations, and chi‐square tests—were performed to
compare findings across groups. Of the 100 T2DM patients analyzed, a
majority exhibited normal thyroid function. However, approximately
one‐fifth showed subclinical abnormalities, such as euthyroid sick
syndrome, subclinical hyperthyroidism, and subclinical hypothyroidism.
The WHR was notably higher among those with diabetes. No participants
showed signs of overt thyroid dysfunction. A mild upward trend in TSH
levels was observed with longer diabetes duration, though this was not
statistically significant. This study highlights the importance of evaluating
thyroid function in patients with diabetes, even in the absence of overt
symptoms. Identifying subclinical thyroid issues could support better
glycemic control and help mitigate the risk of long‐term complications.
ER  -