TY  - JOUR
T1  - A Study on Diagnosis of Helicobacter Pylori Infectionby Culture and Molecular Methods from Gastric Biopsy Specimens and Serological Assays in Patients with Peptic Ulcer Disease
AU - Unnithan, Parameshwaran AU - Samuel, Richard 
JO  - Research Journal of Medical Sciences
VL  - 19
IS  - 4
SP  - 65
EP  - 71
PY  - 2025
DA  - 2001/08/19
SN  - 1815-9346
DO  - makrjms.2025.4.65.71
UR  - https://makhillpublications.co/view-article.php?doi=makrjms.2025.4.65.71
KW  - Helicobacter pylori
KW  - gastric biopsy
AB  - H.pylori are asymptomatic and it may play an important role in the
natural gasric ecosystem. H. pylori infection is more prevalent in
developing countries. The production of the nitrates by bacteria acts as
a factor in the causation of mild gastritis to peptic ulcers. The study was
conducted with the approval from the institutional Ethical Committee,
Sree mookambika institute of medical sciences .Inclusion Criteria are
Adults >18 Years and Patients resenting With Clinical features of Gastric
Ulcer, Duodenal Ulcer, Antral Gastritis And Gastric Carcinoma. Exclusion
Criteria are Patients Who Were On Antibiotics, Proton um Inhibitors Or
Helicobacter Pylori Therapy Within 1 Month prior To This Study. In the
present study, among the patients with peptic ulcer disaese, Epigastric
pain was the predominant symptom (86%) dyspepsia in 80%, vomiting
64%, loss of weight 22%, haematemesis in 12% and melena in 5% of
cases. Similarly Epgastric pain was the predominant symptom among the
patients with gastric carcinoma (89%), followed by vomiting (65%). in
patients with gastric malignancies loss of weight (62%) and loss of
appetite (55%) were strikingly high when compared with the patients
with non malignant lesions. A high preponderance of H.pylori infection
was noted in patients with duodenal ulcer. The inexpensive Rapid urease
test detected maximum number of cases Hence, it is a valuable screening
test which could be used as an adjunct to endoscopy. HpIgG antibody
assays could be employed as a useful screening assay with stringent
quality control measures in place for the estimation of seroprevalence of
Helicobacter pylori among the high risk population. However subsequent
serum samples are required to follow up the severity of the disease.
ER  -